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20/03/2014

Rapid Breathing 'Could Protect Premature Babies'

High-frequency breathing support for premature babies could lead to better lung function in later life, a new study has found.

The research, which has been carried out at King's College London with the findings published in the New England Journal of Medicine, found that premature babies supported immediately after their birth by high-frequency oscillation had better lung function as adolescents than those who received conventional ventilation.

Breathing support can be provided by conventional ventilation, which assists breathing at an individual's breathing rate, or by high-frequency oscillatory ventilation (HFOV). During HFOV, smaller, shorter bursts of gas are delivered.

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For the study, the team followed 319 babies who were born before 29 weeks of gestation. They were followed from their birth through to adolescence, and researchers compared what happened to the lungs of those given conventional ventilation within an hour of being born, with those on high-frequency oscillatory ventilation (HFOV).

It was discovered that the small airways of the children were in better shape between the ages of 11 and 14 if they had had HFOV as a baby, and it is thought this could be because the smaller volume of air being forced into the lungs caused less damage to the organs than conventional therapy.

The difference did not appear to affect children in their daily lives.

Anne Greenough, Professor of Clinical Respiratory Physiology and Head of the School of Medicine at King's College London, said: "Poorer lung function in adolescence could have further consequences later in life, such as making children more vulnerable to the damaging effects of smoking and infection."

Around 60,000 babies are born very prematurely in the UK each year.

(JP/IT)

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"High-frequency breathing support for premature babies could lead to better lung function in later life, a new study has found."